NIVALIN, GALAMTAMINE AN ALKALOID WITH ANTICHOLINESTERASE ACTIVITY !
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NIVALIN (GALANTAMINE) ALKALOID WITH ANTICHOLINESTERASE ACTIVITY
Excessive Decurarizing Drug
Nivalin is an original phytopreparation developed by Sopharma's own research team and produced with an original technology for extraction of the alkaloid Galantamine from the bulbs of the plant snowdrops (Leucojum aestivum). Galantamine is the active ingredient in Nivalin.
NIVALIN (GALANTAMINE) MECHANISM OF ACTION
Nivalin is competitive reversible inhibitor of Acetylcholinesterase (AChE) and prolongs the hydrolysis of endogenous mediator acetylcholine, thereby increasing its accumulation in the choline sensitive postsynaptic membranes.
Adaptation of nicotine cholinesterase transmission for account of the blockage of AChE and the sensibilization of nicotine acetylcholine receptors (nAChR).
Nivalin inhibits reversibly brain, erythrocytic, muscle and serum cholinesterase. Its effect on brain cholinesterase is 10-12 times as potent, compared to physostigmine, since Nivalin crosses the blood-brain barrier.
Nivalin increases the intensity of nerve impulses leading to the muscle tissues, increases muscle contractions and their duration.
Nivalin antagonizes the effect of nondepolarizing neuromuscular blocking drugs. The antagonistic effect develops 20-30 s following parenteral administration and continues 30 to 60 minutes.
Nivalin stimulates the frequency and tone of the gastrointestinal muscle contraction.
Nivalin possesses mild hypotensive effect when administered in small or medium doses and in higher doses has two-phase action.
NIVALIN IN NEUROLOGY NIVALIN IS APPLICABLE IN:
Poliomyelitis (immediately after the febrile period and during the recovery and residual period.
Neuritis, myopathies, myasthenia, progressive muscular dystrophy, cerebral paralysis in childhood, cerebral palsy in neonates. Enuresis nocturna.
Residual paresis following haemorrhagic stroke.
Alzheimer's disease in light and medium stages.
NIVALIN IS APPLICABLE AS WELL IN:
To abolish the effects of nondepolarizing neuromuscular blockers and to treat postoperative paresis and bladder complications.
In some forms of impotence.
In mental retardation.
In poisoning with morphine and its analogues.
In functional diagnostics of the gastrointestinal tract (cholecystography and cholangiography.
In electrophoresis in neuritis of the auditory, facial and other nerves; neuritis, neuropathy, endarteritis obliterans, angioneurosis, acrocyanosis, dyshidrosis and neurodermitis.
RECOMMENDED DOSAGE SCHEMES:
From 1 to 2 years of age:
0.25 - 1.0 mg
From 3 to 5 years of age:
0.50 - 5.0 mg
From 6 to 8 years of age:
0.75 - 7.5 mg
5 - 10 mg
From 9 to 11 years of age:
1.00 - 10.0 mg
5 - 15 mg
From 12 to 15 years of age:
1.25 - 12.5 mg
5 - 25 mg
Over 15 yeas of age of age:
12.50 - 15.0 mg
10 - 40 mg
A treatment course continues for 1 - 2 months and in degenerative diseases of the Central Nervous System up to one year.
Nivalin is a preparation with low toxicity, soft and stable action and possesses wide spectrum of application for therapeutic purposes.
Nivalin is very well tolerated and despite that fact should not be prescribed in conditions of bronchial asthma, bradycardia, angina pectoris, heart failure, epilepsy, hyperkinetic dyskinesia.
SOPHARMA OFFERS NIVALIN IN THE FOLLOWING FORMS:
Ampoules of 1 ml in the concentrations of 1 mg; 2.5 mg; 5 mg and 10 mg
Tablets in concentrations of 5 mg in package of 60 count and 10 mg in package of 20 count.