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Tests conducted with working concentrations of Nivalin from 0.0015 to 1.5 mg/ml added to the nutrient medium of Salmonella typhimurium strains TA97, TA98, TA100, and TA102, with or without microsomal induction system, showed no signs of mutation.
Tests with Nivalin in concentrations from 0.15 mg/ml to 0.000015 mg/ml on peripheral human lyphocytes caused no unplanned DNA synthesis after incubation for 60 min at 37°C, with or without microsomal activating system 89 mix.
Tests for embryotoxicity and teratogenicity of Nivalin were conducted in rats and rabbits. The conclusions were as follows:
Galantamine hydrobromide (Nivalin) is a preparation with low toxicity. As a result, it has broader therapeutic index than the other reversible inhibitors of cholinesterase.
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